Epigenetic Regulation of the DLK1-MEG3 MicroRNA Cluster in Human Type 2 Diabetic Islets
نویسندگان
چکیده
منابع مشابه
DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients
In addition to genetic predisposition, environmental and lifestyle factors contribute to the pathogenesis of type 2 diabetes (T2D). Epigenetic changes may provide the link for translating environmental exposures into pathological mechanisms. In this study, we performed the first comprehensive DNA methylation profiling in pancreatic islets from T2D and non-diabetic donors. We uncovered 276 CpG l...
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82. Logar CM, Brinkkoetter PT, Krofft RD et al. Darbepoetin alfa protects podocytes from apoptosis in vitro and in vivo. Kidney Int 2007; 72: 489–498 83. Bahlmann FH, Song R, Boehm SM et al. Low-dose therapy with the long-acting erythropoietin analogue darbepoetin alpha persistently activates endothelial Akt and attenuates progressive organ failure. Circulation 2004; 100: 1006–1012 84. Menne J,...
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ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2014
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2013.11.016